Siberian Rhubarb Root Extract

Recently available in the United States, Siberian rhubarb root extract has been used by women in Europe as an herbal menopause remedy since 1996.

The reported benefits of Siberian rhubarb root extract has prompted a number of researchers to investigate this herb.

Researchers confirm the safety and efficacy of Siberian rhubarb root extract (ERr 731) in relieving menopause complaints.

Prestigious medical journal Menopause investigates Siberian rhubarb root extract

In 2006 the prestigious medical journal Menopause published an extensive study of Siberian rhubarb root extract. The study followed 109 women with perimenopause related complaints.

54 women were given a specific formula of Siberian rhubarb root extract (called ERr 731 by the researchers) and 55 women were given a placebo (sugar pill) for three months.

The researchers assessed the benefits of Siberian rhubarb root extract with a questionnaire designed for such research, called the Menopause Rating Scale.

This questionnaire allowed the women to report any improvements in menopause related symptoms in eleven different area’s of complaint.

  • hot flushes, sweating (episodes of sweating)
  • heart discomfort (unusual awareness of heart beat, heart skipping, heart racing, tightness)
  • sleep problems (difficulty falling asleep, difficulty in sleeping through, waking up early)
  • depressive mood (feeling down, sad, on the verge of tears, lack of drive, mood swings)
  • irritability (feeling nervous, inner tension, feeling aggressive)
  • anxiety (inner restlessness, feeling panicky)
  • physical and mental exhaustion (general decrease in performance, impaired memory, decrease in concentration, forgetfulness)
  • sexual problems (change in sexual desire, in sexual activity and satisfaction)
  • bladder problems (difficulty urinating, increased need to urinate, bladder incontinence)
  • dryness of vagina (sensation of dryness or burning in the vagina, difficulty with sexual intercourse)
  • joint and muscular discomfort (pain in the joints, rheumatoid complaints)

Researchers report the results of their study

Here’s the reported results of their investigation into Siberian rhubarb root extract (ERr 731). A higher total score on the Menopause Rating Scale reflects a greater number of perimenopause related complaints and more severe complaints.

“By 12 weeks, the [Menopause Rating Scale] total score and each [Menopause Rating Scale] symptom [score] significantly decreased in the ERr 731 group compared to the placebo group.”

“According to the investigators assessments, 49 (90.7%) women taking ERr 731 experienced major improvement.”

“Significant improvements with ERr 731 were also found for each of the 11 symptoms measured by the [Menopause Rating Scale], ie, hot flushes and sweating, heart complaints, sleep disturbances, depressive mood, irritability, anxiety, physical and mental exhaustion, sexual problems, urinary tract complaints, vaginal dryness, and joint and muscle complaints.”

The researchers also asked the women how well they tolerated ERr 731. 91% of the women reported back that the “tolerability” of ERr 731 was very good or good.

Safety of Siberian rhubarb root extract also investigated

The safety of Siberian rhubarb root extract was also investigated in the study above, published in the journal Menopause. Researchers used a long list of tests to identify changes that would suggest a safety risk. Here are their conclusions.

“ERr 731 [was] not associated with any changes in the safety parameters (breast tissue, endometrium, laboratory parameters such as hormones, liver enzymes, and creatinine as well as body weight and blood pressure) assessed in this study.”

Investigation of any side effects experienced when taking Siberian rhubarb root extract

Investigators in the study also evaluated any and all side effects that might be associated with taking Siberian rhubarb root extract. They did so by comparing the complaints of the two groups of women in the study.

One group was taking Siberian rhubarb root extract while the other took a placebo (sugar pill). A very small number of women in both groups attributed some complaints to the pill they were taking (Siberian rhubarb root extract or placebo).

Researchers refer to side effects as “adverse events”. They concluded as follows.

“Adverse events occurred in both treatment groups, but they were equally distributed between the groups and were all assessed to be not related to the intake of the investigational medication [Siberian rhubarb root extract – ERr 731].”

To Buy Estrovera (Siberian rhubarb root extract)


Contains the same form of Siberian rhubarb root extract that was tested by researchers who reported their results in the journal Menopause.

Guarantee: If you are not completely satisfied, return the empty bottle and get your money back 100% with no questions asked.


Answers to frequently asked questions about Siberian rhubarb root extract (ERr 731) and Estrovera– find them here.

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